Simvastatin enhances cytotoxicity induced by chemotherapeutic agents. KBM-5 cells (5000 cells/0.1 mL) were incubated at 37°C with (A), 100 nM doxorubicin; (B), 100 nM paclitaxel; (C), 5 µM 5-fluorouracil in the presence and absence of 5 µM simvastatin as indicated for 24 hours, and viable cells were assayed using the MTT reagent. The results are expressed as mean cytotoxicity ± standard deviation from triplicate cultures. Determinations were made in triplicate. Data represent the mean of three measurements ± SD. *** p <0.001, ** p <0.01.