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. Author manuscript; available in PMC: 2009 Oct 6.
Published in final edited form as: Biochem Pharmacol. 2007 Oct 16;75(4):907–913. doi: 10.1016/j.bcp.2007.10.010

Fig. 5.

Fig. 5

(A). Simvastatin potentiates apoptotic effect induced by chemotherapeutic agents. KBM-5 cells (1 × 106/mL) were incubated with chemotherapeutic agents, alone or in combination with simvastatin, as indicated above, for 24 hours. Cell death was determined by the calcein-AM-based live/dead assay, as described in Materials and Methods. (B). Atorvastain has no effect on paclitaxel induced apoptosis. KBM-5 cells (1 × 106/mL) were incubated with paclitaxel, alone or in combination with atorvastatin, as indicated above, for 24 hours. Cell death was determined by the calcein-AM-based live/dead assay, as described in Materials and Methods. Experiments were performed in triplicate. Data are from one representative experiment.