(A). Simvastatin potentiates apoptotic effect induced by chemotherapeutic agents. KBM-5 cells (1 × 106/mL) were incubated with chemotherapeutic agents, alone or in combination with simvastatin, as indicated above, for 24 hours. Cell death was determined by the calcein-AM-based live/dead assay, as described in Materials and Methods. (B). Atorvastain has no effect on paclitaxel induced apoptosis. KBM-5 cells (1 × 106/mL) were incubated with paclitaxel, alone or in combination with atorvastatin, as indicated above, for 24 hours. Cell death was determined by the calcein-AM-based live/dead assay, as described in Materials and Methods. Experiments were performed in triplicate. Data are from one representative experiment.