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Copper transport in enterocytes. Copper is shown to enter the enterocyte from the blood via hCTR1 and from the intestine through an unidentified mechanism. Copper then binds to copper chaperones, which deliver it to the target proteins, including ATP7A and ATP7B. CTR1 and CTR2 may also be involved in copper release from the intracellular vesicles. TGN, trans-Golgi network.
