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Stereo- and regioselectivity observed in the metabolism of testosterone by CYP2B1 WT and variants
T and A represent testosterone and androstenedione, respectively. The reconstitution, extractions, and analyses of metabolites are described under “Experimental Procedures.”
| CYP2B1 | 16β/16α-OH-T | 16β-OH-T/16β-OH-A |
|---|---|---|
| molar ratio | molar ratio | |
| WT | 1.0 | 2.3 |
| Y309C | 0.8 | 4.5 |
| S360C | 0.7 | 1.6 |
| Y309C/S360C | 1.1 | 9.0 |
