FIGURE 7.
Altered whole body metabolism in Pcyt2+/− mice. A, mice (8, 20, and 36 weeks of age) were subjected to a 24-h fast, and weight loss is expressed as a percentage of body weight (n = 10/group), where an asterisk represents p < 0.05, by Student's t test. C, [14C]oleate oxidation in primary hepatocytes, where the data are expressed as nmol CO2 produced/mg of protein/h (n = at least three livers analyzed in triplicate). B, respiratory quotient (VCO2/VO2) determined by indirect calorimetry over a 24-h period; 36-week-old mice were fasted during the light cycle (7:30 am to 7:30 pm) and fed during the dark cycle (7:30 pm to 7:30 am) (n = 5/group). An asterisk represents statistical significance (p < 0.05) as determined by one-way analysis of variance.