Reduced insulin sensitivity and increased muscle lipid accumulation in Pcyt2+/− mice. A, intraperitoneal glucose tolerance test (IPGTT); where glucose levels were from base line to 120 min (n = 6/group). B, IPGTT insulin levels from base line to 120 min (n = 6/group). Area under the curve for IPGTT glucose and area under the curve for IPGTT insulin are for 36-week old mice. For C and D, an asterisk represents statistical significance (p < 0.05). E, total PL, DAG, and TG content of skeletal muscle of 36-week-old mice (n = 8).