FIGURE 6.

Superposition of external aldimine models between spSRw·d-serine and spSRw·l-serine. The models were designed by taking advantage of the active site superimposition of the rat serine dehydratase complex with O-methyl-l-serine onto spSRm. The substrates, l-serine and d-serine, are shown in green and pink, respectively. The catalytic bases, Lys-57 and Ser-82 (blue), reside on the si- and re-faces of PLP, respectively, and are directed toward the Cα hydrogen atoms. The putative hydrogen bonds between PLP-phosphate and substrate are shown by dotted lines.