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. 2009 Jul 17;284(38):25984–25992. doi: 10.1074/jbc.M109.016808

FIGURE 2.

FIGURE 2.

Treatment with a CAR agonist ameliorated diabetes, whereas CAR−/− mice exhibited spontaneous insulin insensitivity. A and B, treatment with TCPOBOP ameliorated insulin resistance induced by HFD in male C57BL/6J mice, as determined by GTT (A) and ITT (B). Mice were fed with HFD for 8 weeks in the presence or absence of TCPOBOP (0.5 mg/kg, once per week). C and D, ob/ob mice maintained on chow diet were treated with TCPOBOP or vehicle for 8 weeks before subjecting to GTT (C) and ITT (D) tests. *, p < 0.05; **, p < 0.01, compared with the vehicle group. E and F, GTT (E) and ITT (F) tests on CAR−/− mice maintained on chow diet in the presence or absence of 5-week TCPOBOP treatment. *, p < 0.05, CAR−/−-vehicle versus wild type (WT); #, p < 0.05, CAR−/−-TCPOBOP versus wild type.