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. 2009 Jul 17;284(38):25984–25992. doi: 10.1074/jbc.M109.016808

FIGURE 7.

FIGURE 7.

Activation of CAR increased BAT energy expenditure and promoted peripheral fat mobilization. A, BAT mRNA expression of genes involved in energy expenditure and thermogenesis. Male C57BL/6J mice were HFD-fed and TOPOBOP-treated for 1 week. n = 4 for each group. B, oxygen consumption in male C57BL/6J mice HFD-fed and TOPOBOP-treated for 5 weeks. n = 4 for each group. C, WAT mRNA expression of lipase genes. Mice are the same as those described in A. D, food intake without (left) or with (right) normalization against the body weight. Mice are the same as those described in B. E, food intake of ob/ob mice maintained on a chow diet and treated with vehicle or TCPOBOP for 8 weeks. n = 5 for each group. F, hypothalamic mRNA expression of neuropeptides. Mice are the same as those described in B. *, p < 0.05; **, p < 0.01; NS, statistically not significant (p > 0.05) compared with the vehicle group.