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Activation of CAR had little effect on ER stress in the liver. Shown is liver mRNA expression of genes involved in ER stress as determined by real time PCR analysis. A, male C57BL/6J mice were HFD-fed and TOPOBOP-treated for 8 weeks. n = 4 for each group. B, ob/ob mice maintained on a chow diet and treated with vehicle or TCPOBOP for 8 weeks. n = 5 for each group. HMGcoR, HMG-CoA reductase; GPR, G protein-coupled receptor; XBP1, X-box binding protein 1.
