FIGURE 6.

Phosphorylation sites and phosphorylation landscape for UTMP16L. The list at the left shows that 22 residues are potentially capable of acting as kinase substrates with a greater than 0.5 probability. The Ser residues at 85, 89, 95, and 96 have the highest phosphorylation probability scores with casein kinase II (CKII) (green K) even without the possibility that phosphorylation would further enhance the potential for phosphorylation of additional Ser or Thr. residues. Thus, this central region exposed at the exterior of the cell syncytial membranes, but anchored by the transmembrane region to the cell interior, may be important in directing mineral localization. Other potential kinases are protein kinase C (red), protein kinase A (red), and casein kinase I (CKI) (black K). Note that several of the Ser residues may be substrates for either casein kinase I or II.