FIGURE 5.
A, superposition of the loop region of the three Nei enzymes with known structures: MvNei1 (pink), EcoNei (gray; PDB code 1Q3B (30)), and hNEIL1 (cyan; PDB code 1TDH (29)). Two asterisks indicate the start and end of the putative lesion binding loop in MvNei1. B, superposition of the MvNei1 loop (pink) with the αF–β10 loop of the BstFpg·8-oxoG complex (blue; PDB code 1R2Y (48)). C, superposition of the MvNei1·THF complex with the BstFpg·DHU complex (PDB code 1R2Z (48)). The MvNei1 complex is shown in green and the BstFpg complex in blue.