. Author manuscript; available in PMC: 2009 Oct 6.

Published in final edited form as: Alcohol Clin Exp Res. 2008 Jun 28;32(8):1361–1371. doi: 10.1111/j.1530-0277.2008.00722.x

Table 2.

The Effect of Peptide Treatments on the Alcohol-Induced Reduction of 5-HT-im Neurons Is Effective in the Dorsal Than the Median Raphe

	Chow	PF	ALC	ALC + SAL	ALC + NAP	Chow + NAP
Dorsal raphe	4092 ± 241^**	3646 ± 158^**	2795 ± 216	3504 ± 186^*	3171 ± 176	3901 ± 412^**
Median raphe	3339 ± 155^**	3374 ± 113^*	2696 ± 124	2950 ± 118^*	2820 ± 81	2922 ± 207

ALC, alcohol liquid diet; PF, pair-fed; SAL, activity-dependent neurotrophic factor agonist peptide (SALLRSIPA); NAP, activity-dependent neurotrophic protein agonist peptide (NAPVSIPQ); 5-HT-im, 5-HT-immunostained.

The number of 5-HT neurons in the ALC group is significantly reduced as compared with Chow and PF control groups in the dorsal raphe; SAL protect against the alcohol-induced reduction of 5-HT-im neurons. The protection is less effective in the median raphe. After significant difference in anova, the post hoc comparisons listed below were shown between treatments against alcohol group.

Mean ± SEM

p < 0.05

^**

p < 0.01 as compared with ALC.