Fig. 2.
M-LDH physically associated with Kir6.2/SUR2A is required for the KATP channels activation in chemical hypoxia. (A) Current–voltage relationships with corresponding original membrane currents in control cells and cells infected with gly193M-LDH/ΔM-LDH when exposed to DNP (10 mM). Each point represents mean ± SEM (n = 5). (B) Membrane current at 80 mV under control conditions (normoxia) and when exposed to DNP (10 mM) in wild type cells and cells infected with gly193M-LDH/ΔM-LDH. Each bar represents mean ± SEM (n = 5).