Table 5.
Strain | ygaD | recAo | recA | RecX | uvrD | attλ | Other relevant genotype | Origin of reference |
---|---|---|---|---|---|---|---|---|
CAG18491 | + | + | + | + | + | + | metE3079::Tn10 | E.coli Stock Center |
DM1187 | + | + | 730,4162 (recA441) | + | + | + | D. Mount | |
GY8382 | + | + | 938::cat | + | + | + | B. Michel | |
JC13509a | + | + | + | + | + | + | Lab Stock | |
JJC7643 | + | + | + | + | 307 | + | yigE::cat | B. Michel |
K253 | + | + | 730,4164 (recA718) | + | + | + | srlC300::Tn10 | M. Volkert |
KL880 | + | + | + | + | 252 | + | B. Low | |
N14–4 | + | + | + | + | 3 | + | B. Low | |
N3055 | + | + | + | + | + | + | uvrA277::Tn10 | R.G. Lloyd |
SS391 | + | + | 938::cat | + | + | + | GY8382→JC13509c | |
SS996 | + | + | + | + | + | Ωgfp | (McCool et al., 2004) | |
SS1054 | + | + | + | + | + | + | metE3079::Tn10 | (Centore et al., 2009) |
SS1436 | + | + | 938::cat | + | + | Ωgfp | (McCool et al., 2004) | |
SS4070 | + | + | + | + | + | + | del(mutL)100::kan | (Baba et al., 2006) |
SS4073 | + | + | + | + | + | + | del(mutH)100::kan | (Baba et al., 2006) |
SS4539 | + | + | + | + | 252 | + | KL880→SS1054g | |
SS4540 | + | + | + | + | 3 | + | N14–4→SS1054g | |
SS4558 | + | + | + | + | 252 | Ωgfp | gal-76::Tn10 | SS1465→SS4539c |
SS4559 | + | + | + | + | 3 | Ωgfp | gal-76::Tn10 | SS1465→SS4540c |
SS4570 | + | + | + | + | kan | + | (Baba et al., 2006) | |
SS4626 | + | + | + | + | + | Ωgfp | zfj-3131::Tn10 alaS5 | (Long et al., 2008) |
SS4629 | + | + | 730 | + | + | Ωgfp | (Long et al., 2008) | |
SS4630 | + | + | 730,4162 | + | + | Ωgfp | DM1187→SS4626e | |
SS4976 | kan | o1403 | 4142 | + | + | Ωgfp | (Long et al., 2008) | |
SS5130 | + | + | + | + | + | + | del(uvrB)100::kan | (Baba et al., 2006) |
SS5802 | + | + | + | + | + | Ωgfp | metE3079::Tn10 | CAG18491→SS996c |
SS5292 | + | + | 730,4164 | + | + | Ωgfp | srlC300::Tn10 | K253→SS996c |
SS5296 | kan | + | 803,4162 | + | + | Ωgfp | Lab Stock | |
SS5376 | + | + | 730 | + | + | Ωgfp | pDPT429→SS4629d | |
SS5377 | kan | o1403 | 4142 | + | + | Ωgfp | pDPT429→SS4976d | |
SS5737 | + | + | + | + | 701 | Ωgfp | gal-76::Tn10 | (Centore et al., 2009) |
SS5752 | + | + | + | + | + | Ωgfp | uvrA277::Tn10 | N3055→SS996c |
SS5753 | + | + | + | + | 307 | Ωgfp | yigE::cat | JJC2643→SS5802g |
SS5767 | + | + | + | + | + | Ωgfp | del(uvrB)100::kan | SS5130→SS996b |
SS5949 | + | + | + | + | + | Ωgfp | del(mutL)100::kan | SS4070→SS996b |
SS5958 | + | + | del(recA)100::kan | + | + | Ωgfp | SS4952→SS996b | |
SS6013 | kan | + | 4142 | + | + | Ωgfp | SS6009→SS996h | |
SS6089 | kan | o1403 | 4142,4162 | + | + | Ωgfp | SS5323→SS996b, h | |
SS6027 | kan | + | 4164 | + | + | Ωgfp | SS6026→SS996b, h | |
SS6052 | kan | + | 4162 | + | + | Ωgfp | SS6430→SS4630b, h | |
SS6062 | kan | o1403 | 4142,4164 | + | + | Ωgfp | SS6444→SS996b, h | |
SS6074 | + | + | 730 | + | + | Ωgfp | pNR122→SS4629d | |
SS6075 | kan | o1403 | 4142,4164 | + | + | Ωgfp | pNR122→SS4976d | |
SS6076 | kan | o1403 | 4142,4164 | + | + | Ωgfp | pNR123→SS4976d | |
SS6077 | + | + | 730 | + | + | Ωgfp | pNR123→SS4629d | |
SS6078 | kan | o1403 | 4142,4164 | + | + | Ωgfp | pNR124→SS4976d | |
SS6079 | + | + | 730 | + | + | Ωgfp | pNR124→SS4629d | |
SS6080 | + | + | + | cat | + | Ωgfp | (Long et al., 2008) | |
SS6081 | kan | + | 4162 | + | + | Ωgfp | pEL16→SS6052d | |
SS6082 | kan | + | 4164 | + | + | Ωgfp | pEL16→SS6027d | |
SS6085 | kan | + | 4164 | + | + | Ωgfp | pNR127→SS6027d | |
SS6086 | kan | + | 4162 | + | + | Ωgfp | pNR127→SS6052d | |
SS6118 | + | + | del | + | + | Ωgfp | pNR127→SS5958d | |
SS6100 | + | + | del | + | + | Ωgfp | pEL16→SS5958d | |
SS7125 | + | + | + | + | kan | Ωgfp | SS4570→SS996b | |
SS7139 | + | + | + | + | del | Ωgfp | SS7134i | |
SS7434 | kan | 1403 | 4142,4162 | + | del | Ωgfp | SS5323→SS7139b | |
SS7449 | kan | 1403 | 4142,4162 | cat | + | Ωgfp | SS7444→SS996f | |
SS7450 | kan | 1403 | 4142,4162 | cat | del | Ωgfp | SS7444→SS7139f | |
SS7451 | kan | 1403 | 4142,4162 | cat | 701 | Ωgfp | gal-76::Tn10 | SS7444→SS5737f |
SS7457 | kan | 1403 | 4142,4162 | cat | 307 | Ωgfp | yigE::cat | SS7444→SS5753f |
SS7459 | kan | 1403 | 4142,4162 | cat | 252 | Ωgfp | SS7444→SS4558f | |
SS7463 | + | + | 730,4164 | + | del | Ωgfp | srlC300::Tn10 | K253→SS7139c |
SS7464 | + | + | 730,4162 | + | kan | Ωgfp | SS4570→SS4630b | |
SS7465 | kan | 1403 | 4142,4164 | + | del | Ωgfp | SS6444→SS7139b | |
SS7467 | + | + | + | cat | del | Ωgfp | SS6080→SS7139f | |
SS7468 | + | + | + | cat | 252 | Ωgfp | SS6080→SS4558f | |
SS7470 | + | + | + | cat | 701 | Ωgfp | SS6080→SS7139f | |
SS7474 | + | + | 730,4162 | cat | + | Ωgfp | SS7471→SS996j, f | |
SS7475 | + | + | 730,4164 | cat | + | Ωgfp | srlC300::Tn10 | SS7472→SS996j, f |
SS7476 | kan | 1403 | 4142,4164 | cat | + | Ωgfp | SS7473→SS996j, f | |
SS7477 | + | + | 730,4162 | cat | del | Ωgfp | SS7471→SS7139f | |
SS7478 | + | + | 730,4164 | cat | del | Ωgfp | srlC300::Tn10 | SS7472→SS7139f |
SS7479 | kan | 1403 | 4142,4164 | cat | del | Ωgfp | SS7473→SS7139f | |
SS7480 | + | + | + | cat | + | Ωgfp | metE3079::Tn10 | CAG18491→SS6080c |
SS7481 | + | + | + | cat | 307 | Ωgfp | yigE::cat | JJC7643→SS7480g |
SS7485 | + | + | 730,4164 | cat | 3 | Ωgfp | SS7472→SS4559f | |
SS7486 | + | + | 730,4164 | cat | 701 | Ωgfp | SS7472→SS5737f | |
SS7487 | + | + | 730,4164 | cat | 252 | Ωgfp | SS7472→SS4558f | |
SS7488 | + | + | 730,4164 | cat | 307 | Ωgfp | yigE::cat srlC300::Tn10 | SS7472→SS5753c |
SS7489 | kan | 1403 | 4142,4162 | cat | 3 | Ωgfp | SS7444→SS4559f | |
SS7604 | + | + | + | + | + | Ωgfp | del(mutH)100::kan | SS4073→SS996b |
SS7605 | + | + | + | + | + | Ωgfp | del(mutS)100::kan | SS4882→SS996b |
SS7611 | kan | o1403 | 4142,4162 | cat | + | Ωgfp | del(mutL)100::kan | SS7444→SS5949j, f |
SS7612 | kan | o1403 | 4142,4162 | cat | + | Ωgfp | del(uvrB)100::kan | SS7444→SS5767f |
SS7613 | + | + | 730,4164 | cat | + | Ωgfp | del(mutL)100::kan srlC300::Tn10 | SS7472→SS5949j, f |
SS7614 | + | + | 730,4164 | cat | + | Ωgfp | del(uvrB)100::kan srlC300::Tn10 | SS7472→SS5767f |
SS7615 | kan | 1403 | 4142,4162 | cat | + | Ωgfp | del(uvrA)100::kan | SS7444→SS5752f |
SS7616 | + | + | 730,4164 | cat | + | Ωgfp | del(uvrA)100::kan srlC300::Tn10 | SS7472→SS5752f |
SS7617 | kan | 1403 | 4142,4162 | cat | + | Ωgfp | del(mutS)100::kan | SS7444→SS7605f |
SS7618 | + | + | 730,4164 | cat | + | Ωgfp | del(mutS)100::kan srlC300::Tn10 | SS7472→SS7605f |
SS7619 | kan | 1403 | 4142,4162 | cat | + | Ωgfp | del(mutH)100::kan | SS7444→SS7604f |
SS7620 | + | + | 730,4164 | cat | + | Ωgfp | del(mutH)100::kan srlC300::Tn10 | SS7472→SS7604f |
JC13509 has the following genotype: sulB103 lacMS286 φ 80dIIlacBK1 argE3 hi-4 thi-1 xyl-5 mtl-1 rpsL31 tsx. The lacMS286φ80dIIlacBK1 code for two partial non-overlapping deletions of the lac operon (Konrad, 1977; Zieg and Kushner, 1977). Full notation for ygaD mutation is ygaD1::kan. Full notation for Ωgfp mutation is Δattλ::sulApΩgfp-mut2.
Select for KanR and then screen for other marker phenotypically or by PCR.
Select for TetR and then screen for other marker phenotypically or by PCR.
Select for AmpR
Select for AlaS+
Select for CatR
Select for Met+
These recAo or recA mutations were first constructed on a plasmid as described in the Materials and Methods. They were then transferred to the chromosome using the method of Datsenko and Wanner (Datsenko and Wanner, 2000) using a strain that was lexA3 malE::Tn10 in a JC13509 background with pKD46 encoding exo and bet. This original combination of mutants were named and saved as the strain indicated as the donor in this cross.
This deletion allele was created by first transducing the kan resistant derivative from the Keio collection into the strain as indicated in the reference column. pLH29, carrying the flp gene, was then introduced and Kan sensitive derivatives were screened.
recX::cat was amplified with prSJS748,749 using pACYC184 (New England Biolabs) as a template. recX::cat was transferred to the chromosome using the exo-bet method next to the recA allele indicated. This original combination of mutants were named and saved as the strain indicated as the donor in this cross.