Table I.

Analysis of Stress Responsive Genes Induced by Single-Walled Carbon Nanotubes in BJ Foreskin Cells

Spot #	Gene symbol	Gene name	Fold changea
1	ANXA5	Annexin A5	1.24
2	ATM	Ataxia telangiectasia mutated	1.57
3	BAX	BCL2-associated X protein	1.41
4	BCL2L1	BCL2-like 1	1.43
5	BCL2L2	BCL2-like 2	0.91
6	CASP1	Caspase 1, apoptosis-related cysteine protease	1.27
7	CASP 10	Caspase 10, apoptosis-related cysteine protease	1.21
8	CASP8	Caspase 8, apoptosis-related cysteine protease	1.54
9	CAT	Catalase	1.50
10	CCNC	Cyclin C	1.59
11	CCND1	Cyclin Dl (PRAD1: parathyroid adenomatosis 1)	1.23
12	CCNG1	Cyclin G 1	1.78
13	CDKN1A	Cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.96
14	CHEK2	CHK2 checkpoint homolog (S. pombe)	1.06
15	CRYAB	Crystallin, alpha B	1.01
16	CSF2	Colony stimulating factor 2	1.80
17	CYP1A1	Cytochrome P450, family 1, subfamily A,	1.34
18	CYP1B1	Cytochrome P450, family 1, subfamily B,	1.84
19	CYP2E1	Cytochrome P450, family 2, subfamily E,	1.43
20	CYP7A1	Cytochrome P450, family 7, subfamily A,	1.57
217	CYP7B1	Cytochrome P450, family 7, subfamily B,	1.27
22	DDB1	Damage-specific DNA binding protein 1,	1.35
23	DDIT3	DNA-damage-inducible transcript 3	1.46
24	DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	1.55
25	DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4	1.55
26	E2F1	E2F transcription factor 1	1.17
27	EGR1	Early growth response 1	1.51
28	EPHX2	Epoxide hydrolase 2, cytoplasmic	1.16
29	ERCC1	Excision repair cross-complementing group 1	1.38
30	ERCC3	Excision repair cross-complementing group 3	1.68
31	ERCC4	Excision repair cross-complementing group 4	2.10
32	ERCC5	Excision repair cross-complementing group 5	1.94
33	FMO1	Flavin containing monooxygenase 1	1.54
34	FMO5	Flavin containing monooxygenase 5	0.94
35	GADD45A	Growth arrest and DNA-damage-inducible, alpha	1.40
36	GADD45B	Growth arrest and DNA-damage-inducible, beta	1.27
37	GPX1	Glutathione peroxidase 1	1.03
38	GSR	Glutathione reductase	1.23
39	GSTM3	Glutathione S-transferase M3 (brain)	1.08
40	HMOX1	Heme oxygenase (decycling) 1	2.07
41	HMOX2	Heme oxygenase (decycling) 2	3.14
42	HSF1	Heat shock transcription factor 1	1.36
43	HSPH1	Heat shock 105 kDa/110 kDa protein 1	1.13
44	HSPA1A	Heat shock 70 kDa protein 1A	1.40
45	PTGS1	Prostaglandin-endoperoxide synthase 1	1.11
46	HSPA1L	Heat shock 70 kDa protein 1-like	1.47
47	HSPA2	Heat shock 70 kDa protein 2	1.12
48	HSPA4	Heat shock 70 kDa protein 4	1.30
49	HSPA5	Heat shock 70 kDa protein 5	1.80
50	HSPA6	Heat shock 70 kDa protein 6	1.26
51	HSPA8	Heat shock 70 kDa protein 8	1.18
52	HSPA9B	Heat shock 70 kDa protein 9B	1.07
53	HSPB1	Heat shock 27 kDa protein 1	0.83
54	HSPCA	Heat shock 90 kDa protein 1, alpha	1.04
55	HSPCB	Heat shock 90 kDa protein 1, beta	0.92
56	HSPD1	Heat shock 60 kDa protein 1	1.43
57	HSPE1	Heat shock 10 kDa protein 1	2.35
58	IGPBP6	Insulin-like growth factor binding protein 6	1.19
59	IL18	Interleukin 18	1.77
60	IL1A	Interleukin 1, alpha	1.27
61	IL1B	Interleukin 1, beta	1.03
62	IL6	Interleukin 6 (interferon, beta 2)	0.81
63	LTA	Lymphotoxin alpha	0.81
64	MDM2	Mdm2, transformed 3T3 cell double minute 2,	1.31
65	MIF	Macrophage migration inhibitory factor	1.45
66	PRDX1	Peroxiredoxin 1	1.26
67	PRDX2	Petoxiredoxin 2	1.25
68	MT2A	Metallothionein 2A	1.21
69	NFKB1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)	0.85
70	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	1.46
71	NOS2A	Nitric oxide synthase 2A	1.33
72	PCNA	Proliferating cell nuclear antigen	0.92
73	GDF15	Growth differentiation factor 15	1.76
74	POR	P450 (cytochrome) oxidoreductase	1.48
75	PTGS2	Prostaglandin-endoperoxide synthase 2	1.16
76	RAD23A	RAD23 homolog A (S. cerevisiae)	1.10
77	RAD50	RAD50 homolog (S. cerevisiae)	1.03
78	CCL21	Chemokine (C-C motif) ligand 21	1.40
79	CCL3	Chemokine (C-C motif) ligand 3	1.25
80	CCL4	Chemokine (C-C motif) ligand 4	1.34
81	CXCL10	Chemokine (C-X-C motif) ligand 10	1.23
82	SERPINE1	Serine (or cysteine) proteinase inhibitor	1.19
83	SOD1	Superoxide dismutase 1	0.92
84	SOD2	Superoxide dismutase 2,	0.88
85	TNF	Tumor necrosis factor	1.14
86	TNFRSF1A	TNF receptor superfamily, member 1A	0.91
87	TNFSF10	TNF (ligand) superfamily, member 10	1.38
88	FASLG	Fas ligand (TNF superfamily, member 6)	0.92
89	TP53	Tumor protein p53 (Li-Fraumeni syndrome)	1.58
90	TRADD	TNFRSF1A-associaled via death domain	1.03
91	UGT1A10	UDP glycosyltransferase 1 family	1.03
92	UNG	Uracil-DNA glycosylase	0.77
93	XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	1.19
94	XRCC2	X-ray repair complementing defective repair in Chinese hamster cells 2	1.21
95	XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	1.19
96	XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5	1.14

^aFold Changes represent the ratio of spot density of treated samples divided those by control. The density values were normalized to beta actin before obtaining the fold changes.