Table 2.

Palladium-Catalyzed Carboamination of N-Protected γ—Aminoalkenes with Functionalized Aryl Bromides^a

entry	amine	aryl bromide	product	dr	yieldb
1					75
2					82
3					78e
4					76e
5					79
6					76c,e
7					88 17d
8				—	88e
9				12:1	80
10				15:1	76
11				>20:1	75
12				>20:1	74
13				>20:1	71
14				>20:1	73

^aConditions: 1.0 equiv amine, 1.2 equiv ArBr, 2.3 equiv Cs₂CO₃, 2 mol % Pd(OAc)₂, 4 mol % Dpe-phos, dioxane (0.2–0.25 M), 100 °C.

^bYield refers to average isolated yield obtained in two or more experiments.

^cDppe used in place of Dpe-phos.

^dNaOtBu used in place of Cs₂CO₃.

^eThe reaction wasconducted at 85 °C in DME solvent.