Table I.

Sampling Designs Evaluated for Estimation of Parameter Accuracy and Precision

Design	Model	Model drug	Sampling windows (EC50 units)a
			(1)	(2)	(3)	(4)	(5)
1	Sigmoid E max	Remifentanil	0.1–1	1–2	2–2.5	2.5–3	NS
	E max	Octreotide
2	Sigmoid E max	Remifentanil	0.1–0.5	0.5–1.5	2–2.5	2.5–3	NS
	E max	Octreotide
3S	Sigmoid E max	Remifentanil	0.1–0.5	0.5–1	1–1.5	1.5–2	2–3
4S	Sigmoid E max	Remifentanil	0.1–0.5	0.5–1.5	1.5–2	2–2.5	2.5–3
3E	E max	Octreotide	0.1–0.5	0.5–1	1–1.5	2.5–3	NS
4E	E max	Octreotide	0.1–0.5	0.5–1	1–1.5	1–1.5	2.5–3

NS not sampled

^aRepresents sampling intervals in terms of EC₅₀ units; for each design a single sample was obtained within each window