Table 4.
Joint analysis of the Rotterdam Study results and ARIC plus CHS results (18)
| rs12567209 | rs16847548 | |||||
|---|---|---|---|---|---|---|
| Allelic | Dominant | Allelic | ||||
| ARIC+ CHS | ||||||
| HR | 0.57 | 0.53 | 1.31 | |||
| Ln(HR) | −0.562 | −0.635 | 0.270 | |||
| SE | 0.192 | 0.201 | 0.089 | |||
| P-value | 0.0035 | 0.0015 | 0.0024 | |||
| RS | All | Witnessed | All | Witnessed | All | Witnessed |
| HR | 0.85 | 0.69 | 0.80 | 0.70 | 1.18 | 1.40 |
| Ln(HR) | −0.165 | −0.378 | −0.229 | −0.364 | 0.165 | 0.339 |
| SE | 0.204 | 0.311 | 0.217 | 0.318 | 0.117 | 0.153 |
| P-value | 0.42 | 0.23 | 0.29 | 0.25 | 0.16 | 0.027 |
| Joint | ||||||
| HR | 0.69 | 0.60 | 0.64 | 0.57 | 1.26 | 1.33 |
| Ln(HR) | −0.374 | −0.511 | −0.448 | −0.558 | 0.232 | 0.287 |
| SE | 0.140 | 0.164 | 0.147 | 0.170 | 0.071 | 0.077 |
| P-value | 0.0074 | 0.0018 | 0.0024 | 0.0010 | 0.0011 | 0.00019 |
All results are based on sex and age adjusted allelic models. P-values in bold reflect increased significance with the addition of RS results. ARIC, Atherosclerosis Risk in Communities study; CHS, Cardiovascular Health Study; Ln(HR), natural log of the hazard ratio=beta estimate from Cox regression model; SE, standard error of the regression coefficient; RS, Rotterdam Study.