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Changes in adhesion molecule expression in PBC and PSC
| Adhesion molecule | Portal vein | Sinusoidal EC | Bile ducts | ||||||
|---|---|---|---|---|---|---|---|---|---|
| normal | PBC | PSC | Normal | PBC | PSC | Normal | PBC | PSC | |
| ICAM-1 | −/(+) | ++ | ++ | + | ++ | ++ | − | −/+ | −/+ |
| VCAM-1 | −/(+) | ++ | ++ | ++ | ++ | − | −/(+) | −/(+) | |
| VAP-1 | + | + | + | + | + | + | − | − | − |
| MAdCAM-1 | − | + | + | − | + | + | − | − | − |
“−/(+)” negative or occasionally weakly positive. “−/+” negative in some, positive in other patients
