Table 1.
Animal models of primary sclerosing cholangitis
| Animal | Treatment | IBD | Portal Inflammation | Biliary strictures |
|---|---|---|---|---|
| Rat [47] | N-formyl l-methionine l-leucine l-tyrosine | Yes (acetate-induced) | Macrophages/neutrophils (early) T cells (late) | Unknown |
| Rat [48–50, 133] | Self-filling jejunal blind loops | No | Yes | Fibrosis, strictures not documented |
| CD-1 mouse [55] | Dextran sulfate sodium | Yes | Yes | Unknown |
| Cftr−/− [57] | Dextran sulfate sodium | Yes | Yes | Unknown |
| SAMP1/YitFc [58] | None | Yes | Yes | Unknown |
| Mdr2−/− [59] | None | No | Yes | Yes |