Table 1.
Mean (± SD) test and retest values of plasma input and reference tissue methods together with a simple ratio
| ROI | 2T4k (DVR) | 2T4k (BP2T4k + 1) | 2T4k (VT) | SRTM (BPND + 1) | Parametric SRTM2 (BPND + 1) | SUVr | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Test | Retest | Test | Retest | Test | Retest | Test | Retest | Test | Retest | Test | Retest | |
| AD parietal | 1.76 (0.48) | 1.87 (0.39) | 3.43 (1.05) | 3.69 (0.88) | 6.67 (2.05) | 6.93 (1.69) | 1.67 (0.35) | 1.71 (0.32) | 1.75 (0.36) | 1.80 (0.33) | 1.93 (0.49) | 2.04 (0.40) |
| AD sensory motor Cx | 1.50 (0.44) | 1.57 (0.33) | 3.16 (1.01) | 3.29 (0.78) | 5.69 (1.88) | 5.83 (1.49) | 1.51 (0.30) | 1.55 (0.35) | 1.41 (0.25) | 1.44 (0.24) | 1.63 (0.41) | 1.71 (0.32) |
| Control parietal | 1.19a (0.10) | 1.14 (0.11) | 2.77b (0.96) | 2.66 (1.12) | 5.09c (2.16) | 4.94 (2.60) | 1.32d (0.22) | 1.27 (0.23) | 1.12e (0.22) | 1.09 (0.21) | 1.25f (0.18) | 1.22 (0.18) |
| Control sensory motor Cx | 1.17 (0.06) | 1.13 (0.08) | 2.75 (0.99) | 2.65 (1.12) | 4.98 (2.02) | 4.89 (2.52) | 1.39 (0.25) | 1.33 (0.18) | 1.10 (0.13) | 1.07 (0.13) | 1.24 (0.12) | 1.21 (0.12) |
Compared to AD parietal: ap < 0.05, bp = 0.36, cp = 0.30, dp < 0.10, ep < 0.01, fp = 0.01
In the case of 2T4k, n = 4 and 5 for Alzheimer patients and healthy controls, respectively; in the case of SRTM, parametric SRTM2 and SUVrn = 6 for both patient groups
ROI region of interest, AD Alzheimer’s disease, Cx cortex