Fig. 1.

Voluntary running distances and indices of cardiac hypertrophy. a Mean daily voluntary running distances in 37 rats. b Heart weight to body weight (HW:BW SED n = 32, TRN n = 37), ventricular weight to body weight (VW:BW SED n = 22, TRN n = 29) and left ventricular weight to body weight (LVW:BW SED n = 16, TRN n = 21) ratios for TRN and SED rats. All three ratios were significantly greater in TRN compared to SED rats (*, unpaired t test, P < 0.001 HW:BW, P < 0.05 LVW:BW, Mann Whitney rank sum test, P = 0.002, VW:BW)