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Transmural gradient of Ito in myocytes from trained and sedentary rats. The difference between the mean EPI and mean ENDO Ito currents (EPI-ENDO current) from Fig. 2 is plotted as a transmural gradient of Ito for TRN and SED myocytes. The transmural gradient of Ito is significantly reduced in TRN rats over the range of voltages shown (*P < 0.05, two-way ANOVA, n = 12 TRN, 10 SED hearts)
