Fig. 6.
Simulated action potentials and pseudo-ECGs under trained and sedentary conditions. a Superimposed action potentials of ENDO and EPI cells under SED (S) and TRN (T) modelling changes in EPI Ito. TRN prolonged APD and attenuated transmural APD dispersion. b Space–time plot of AP propagation across the 1D transmural ventricular strand. Membrane potential of cells along the strand is mapped into a colour spectrum ranging from dark blue for −80 mV to red for +40 mV (see colour key). Space runs vertically from the ENDO end at the bottom to the EPI end at the top. Time runs horizontally (left to right). c Simulated pseudo-ECG for SED and TRN conditions (see “Methods”) calculated from b. TRN conditions prolonged the QT interval and inverted the T-wave