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Intracellular Trafficking of Oligonucleotides. RGD-623-Tamra is a 2′-OMe-PS antisense oligonucelotide that has a 5′-RGD targeting ligand and a 3′-Tamra fluorophore. Its distribution in cells is compared to that of caveolin (A) or the avb3 integrin (B) (its receptor) as visualized by immunostaining. Fletchings indicate areas of overlap. Adapted from reference 5 with permission.
