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. Author manuscript; available in PMC: 2009 Oct 6.
Published in final edited form as: Annu Rev Neurosci. 2001;24:677–736. doi: 10.1146/annurev.neuro.24.1.677

Figure 2.

Figure 2

Schematic diagram of p75NTR-mediated signal transduction pathways. P75NTR interacts with proteins, including TRAF6, RhoA, NRAGE (neurotrophin receptor-interacting MAGE homologue), SC-1, and NRIF, and regulates gene expression, the cell cycle, apoptosis, mitogenic responses, and growth cone motility. Binding of neurotrophins to p75NTR has also been shown to activate the Jun kinase pathway, which can be inhibited by activation of the Ras-phosphatidylinositol-3-kinase (PI3K) pathway by Trk receptors. Similar to Figure 1, adaptor proteins are red, kinase green, small G proteins blue, and transcription factors brown. (See text for abbreviations.)