TABLE 2.

Neuronal losses in other neurotrophic factor and receptor-deficient mice^a

Determinant	GDNFg	Neurturinb, g	GFRα1c, g	GFRα2d	GFRα3e	c-retf, g	CNTFRα	LIFR
Sensory ganglia	NS	70% reduction of GFRα2(+)neurons	NS	NS
Trigeminal					NS		NS
N-P	40%	NS	15%	NS
Vestibular	NS		NS
Cochlear	ND
Dorsal root	23%	45% reduction of pfGFRα2(+)neurons	NS	NS	NS		NS
Comments	GFRα1 neurons lost in trigeminal ganglion	68% and 45% loss of GFRα2- expressing neurons in trigeminal and DRG		Only 10% of trigeminal neurons express GFRα2
Sympathetic ganglia
SC	35%	NS	NS	ND	ML	ML	NS
Parasympathetic ganglia
Ciliary	40%	48%	ND	NS		48%
Submandibular	36%	45%	33%	81%	NS	30%
Otic	86%	NS (reductions in neuronal size)	NS			99%
Enteric nervous system
Stomach	ML		ML		NS
Intestine/colon	100%	NS	100%		NS
		Reduced VIPC & SPC fibers; reduced neuronal size		Reduced fiber density
Motor
Facial	NS		NS				40%	35%
Trigeminal	19%		22%				35%
Spinal cord	22%	NS		24%				40%
CNS	No deficit in TH+ neurons		No deficit in TH+ neurons
Viability	VP	G	VP	PM	G	G	VP	VP

^aNote: Similar to Table 1, neuronal losses are expressed as the percentage of neurons lost in the mutants compared with the wild-type controls. See Reichardt & Fariñas (1997) for references of older papers. NS, Not significant; ND, not done; N-P, nodose-petrosal; SC, superior cervical; DRG, dorsal root ganglia; ML, most lost; VP, very poor; G, good, PM, poor to moderate.

^bHeuckeroth et al 1999.

^cCacalano et al 1998, Enomoto et al 1998.

^dRossi et al 1999.

^eNishino et al 1999.

^fDurbec et al 1996, Taraviras et al 1999.

^gEnomoto et al 2000.