Table 4.
Multivariate Cox regression analysis of risk factors at baseline for all-cause mortality—IS entered as tertiles.
| Models of Patient Survival (event n = 25) | RR | 95% CI | P |
|---|---|---|---|
| Unadjusted (GF = 17; P < 0.0001) | |||
| IS 1st tertile | 1.00e | 0.011 | |
| IS 2nd tertile | 8.735 | 1.092 to 69.860 | 0.041 |
| IS 3rd tertile | 17.112 | 2.268 to 129.091 | 0.006 |
| Model 1a(GF = 31; P < 0.0001) | |||
| IS 1st tertile | 1.00e | 0.004 | |
| IS 2nd tertile | 7.389 | 0.910 to 59.912 | 0.061 |
| IS 3rd tertile | 19.875 | 2.594 to 152.265 | 0.004 |
| Model 2b (GF = 25; P < 0.0001) | |||
| 1st tertile | 1.00e | 0.030 | |
| 2nd tertile | 8.366 | 1.030 to 67.930 | 0.047 |
| 3rd tertile | 13.767 | 1.797 to 105.483 | 0.012 |
| Model 3c (GF = 29; P < 0.0001) | |||
| 1st tertile | 1.00e | 0.025 | |
| 2nd tertile | 6.595 | 0.809 to 53.760 | 0.078 |
| 3rd tertile | 12.934 | 1.701 to 98.336 | 0.013 |
| Model 4d (GF = 18; P < 0.0001) | |||
| 1st tertile | 1.00e | 0.035 | |
| 2nd tertile | 7.087 | 0.871 to 57.664 | 0.067 |
| 3rd tertile | 12.584 | 1.646 to 96.236 | 0.015 |
GF, goodness of fit; RR, risk ratio; CI, confidence interval. Tertiles are ordered from low serum IS levels to high levels. Please refer to Table 1 for cut-off values.
a
Model 1 was adjusted for age (in decades), diabetes status, and male gender.
b
Model 2 was adjusted for serum albumin (in 1g/L increments), hemoglobin (in 1-g/L increments), and phosphate (in 1-mMol/L increments) levels.
c
Model 3 was adjusted for the aortic calcification score on CT (in 1% increments) and PWV (in 1-m/s increments).
d
Model 4 was adjusted for the aortic calcification score on x-ray (in 1-unit increments).
e
Reference value; P values for trend across categories.