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. 2009 May 8;3:89–101. doi: 10.4137/grsb.s2210

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© 2009 by the authors

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Kaplan-Meier survival analysis for mice administered a single intravenous injection of GNE-lipoplex. Mice were administered a single intravenous injection of 0 μg, 10 μg, 40 μg, or 100 μg GNE-lipoplex. Survival was observed over 2 weeks. Four of 12 mice in 100 μg GNE-lipoplex cohort died within 24 hours after injection. The remaining eight mice in the 100 μg GNE-lipoplex cohort and 2 mice in 40 μg GNE-lipoplex cohort showed acute toxicity (ruffled coat, hunched posture) within 24 hr of IV injection, but recovered within 48 hours and survived for 2 weeks.