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. 2009 Oct 7;101(19):1308–1324. doi: 10.1093/jnci/djp280

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© The Author 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Probability of survival by worst grade of skin toxicity in patients with metastatic colorectal cancer who were treated with EGFR-targeted monoclonal antibodies in two randomized phase III studies. A) Patients treated with panitumumab. Data are from a landmark analysis that was limited to patients with progression-free interval of at least 28 days (13) (with permission from the American Society of Clinical Oncology. B) Patients treated with cetuximab (12). Reproduced with permission from the New England Journal of Medicine. Copyright 2007 Massachusetts Medical Society. All rights reserved. CI = confidence interval; HR = hazard ratio.