Table 1.
Potency (in μM) of 1, 2 and related compounds against mDia1-FH2 actin assembly.
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R1 | R2 | R3 | R4 | R5 | IC50 | |
1 | 0.5 | |||||
2 | H | Br | NH2 | H | H | 2.1 |
2.3 | H | NO2 | NH2 | H | H | 2.6 |
2.4 | H | NO2 | NH2 | CH3 | CH3 | 1.2 |
2.5 | H | Br | NHAc | H | H | > 50 |
2.6 | H | Br | NHMe | H | H | > 50 |
2.7 | CH3 | Br | NH2 | H | H | > 50 |
2.8 | H | -- | NH2 | H | H | > 50 |
2.9 | H | F | NH2 | H | H | > 50 |
2.10 | H | Cl | NH2 | H | H | > 50 |