. Author manuscript; available in PMC: 2010 Oct 13.

Published in final edited form as: Biochemistry. 2009 Oct 13;48(40):9327–9329. doi: 10.1021/bi901354z

Table 2.

Inhibitor selectivity (IC₅₀/Hill coefficients in μM).

	mDia1		mDia2		mDia3		FRL1		INF2
	IC₅₀	nH	IC₅₀	nH	IC₅₀	nH	IC₅₀	nH	IC₅₀	nH
1	0.5	2.4	0.2	2.8	3.1	3.0
2	2.1	7.6	2.2	6.3	>50	---	14.7	2.1	3.5^†	0.9
2.3	2.6	8.3	2.7	4.5	>50	---	23.4	1.8	5.3^†	1.8
2.4	1.2	1.5	0.8	1.9	>50	---

^†

INF2 max. inhibition was only 69% (2) and 75% (2.3). See Fig. 1F.