1 Clinical |
Symptoms – chest pain, severe headache, dizziness, chills, sustained nausea, inappropriate dyspnoea
Signs – sustained pallor, clammy skin, disorientation, inappropriate affect
Patient requests termination of the study
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2 ECG |
Failure of heart rate to increase with exercise, and extreme fatigue, dizziness, or other symptoms suggestive of insufficient cardiac output
Premature ventricular contractions (PVCs) with increasing frequency
Ventricular tachycardia (run of >3 PVCs)
Supraventricular tachycardia
ST segmental depression, or elevation, of more than 3 mm
Triggering of atrioventricular (AV) block (2nd degree AVblock type Mobitz or 3rd degree AV block) by exercise
Triggering of QTc lengthening >500 ms
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3 Blood pressure |
Excessive levels (age-dependent) – systolic blood pressure 250 mmHg, diastolic blood pressure 125 mmHg
Progressive fall in systolic blood pressure with increasing workload
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4 Progressive fall in oxygen saturation to <90% or a 10-point drop from resting saturation in a symptomatic patient. |