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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Hepatology. 2009 Sep;50(3):834–843. doi: 10.1002/hep.23052

Figure 6. Changes of EGFR and related signaling molecules in mice with altered expression of COX-2.

Figure 6

The COX-2 Tg, COX-2 KO and wild type mice were injected intraperitoneally with saline or Jo2 (0.5 µg/g body weight). The livers were harvested 4 hours after the injection and the liver tissues were then homogenized. The obtained cellular proteins were subjected to SDS-PAGE and Western blot analysis to determine the protein levels of EGFR and its related signaling molecules, including phospho-PTEN, phospho-Akt, Akt, Mcl-1, and Bcl-xL. Western blot for GAPDH was shown as the loading control. The blots in this figure were obtained from two individual mice for each group.