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| PSADT = (0.693 × t) / [In (PSA2) – In (PSA1)] |
| Where: “t” is the time (in days) between PSA measurements, “PSA2” is the PSA defining HRPC (third rising PSA), “PSA1” is the next available PSA level |
PSA = prostate-specific antigen; PSADT = prostate-specific antigen doubling time; HRPC = hormone-refractory prostate cancer
