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. Author manuscript; available in PMC: 2009 Oct 7.
Published in final edited form as: Neuron. 2003 Oct 30;40(3):501–514. doi: 10.1016/s0896-6273(03)00666-4

Figure 5. Defective Radial Glia in fak−/− Cortex.

Figure 5

Fluorescent micrographs of frozen sections (20 µm) from E16 heterozygous (A, B, and C) and fak mutant (D, E, and F) cortex stained with RC2 antibodies to label radial glia processes and DAPI to visualize individual cell nuclei. The tufted endfeet of radial glial cells were prominently stained at this stage, where they contribute to the cortical basement membrane (A). Cortical ectopias within the marginal zone of the fak mutant are marked by asterisks (D and E) and coincided with interrupted RC2 staining due to retracted and disorganized radial glial processes. Occasionally, radial glial processes were seen extending through the ectopic clusters. mz, marginal zone. Scale bar, 100 µm.