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. 2009 Oct 12;4(10):e7422. doi: 10.1371/journal.pone.0007422

Figure 4. Silencing of LRP1 inhibits expression of adipocyte differentiation markers in a LRP1 dose-dependent manner.

Figure 4

(A) mRNA expression of LRP1, PPARγ, HSL and aP2 in LRP1 siRNA1-silenced preadipocytes. RNA expression of LRP1, PPARγ, HSL and aP2 was analysed in 3T3F442A preadipocytes transfected with Luc siRNA or LRP1 siRNA1. RNA was quantified by RT-PCR in 3T3F442A cells after 3 and 7 days in adipogenic differentiation medium. Mean ± SD of 4 independent experiments is shown. *P<0.025 when compared with Luc siRNA transfected cells. (B) Inhibition of PPARγ, HSL and aP2 mRNA expression in LRP1-silenced preadipocytes in a LRP1 dose-dependent manner. RNA levels of LRP1, PPARγ, HSL and aP2 in 3T3F442A preadipocytes transfected with Luc siRNA or the 3 LRP1 siRNA1-3 were performed as described in panel A.