Table 1. Hematopoietic roles of validated IL-3 posttranscriptional targets.
Gene name | position in rank list | Notes | reference |
Pik3cd (PI3-kinase delta) | 3 | •associated with myeloid leukemia | [52], [53]. |
•supports leukemic cell growth and survival | |||
IL-6 | 5 | • affects differentiation or proliferation | [54] |
•produced by AML blasts | |||
zfp36l1 (Brf1, tis11b) | 13 | •associated with t(8∶11) myeloid leukemia proliferation | [55] |
cdkn1a (p21) | 14 | •inhibits 32D differentiation | [27], [56] |
•associated with resistant AML | |||
zfp36l2 (Brf2, tis11d) | 39 | •upregulated in resistant myeloid leukemia | [57], [58] |
•involvement at a leukemic breakpoint | |||
myb | 58 | •role in hematopoiesis and promotion of leukemia | [59]–[61] |
•inhibits 32Dcl3 differentiation and apoptosis | |||
pim-1 | 103 | •role in Flt3-mediated survival in myeloid leukemia | [62] |
cited-2 | 273 | •essential for hematopoiesis | [63] |
The ranked position (out of 22,690 probe sets assayed) of Northern-blot-validated transcript probe sets and references highlighting their role in normal or malignant hematopoiesis are shown. For transcripts linked to multiple probe sets, the first occurrence of transcript in the ranked probe set list is shown.