Table 1. Fractions of MHC class I and II ligand-containing proteins that belong to a selection of GO cellular component terms.
Gene Ontology Term | Fraction, MHCI | Corrected P-value, MHCI | Fraction, MHCII | Corrected P-value, MHCII | Fraction, background |
cell | 96.8% | 2.05E-13 | 92.4% | 0.443 | 91.1% |
intracellular | 86.7% | 3.07E-60 | 61.6% | 0.938 | 65.3% |
organelle | 69.3% | 1.23E-33 | 49.2% | 0.861 | 51.5% |
cytoplasm | 62.4% | 8.88E-52 | 52.4% | 4.42E-03 | 40.2% |
nucleus | 39.9% | 3.57E-15 | 10.8% | 1 | 28.8% |
macromolecular complex | 32.6% | 2.94E-54 | 25.4% | 8.58E-04 | 14.6% |
cytosol | 17.7% | 3.88E-52 | 12.4% | 1.42E-03 | 5.3% |
organelle lumen | 15.1% | 1.04E-20 | 5.9% | 0.861 | 7.0% |
ribonucleoprotein complex | 10.6% | 7.69E-26 | 1.6% | 0.995 | 3.6% |
cytosolic ribosom | 4.1% | 3.93E-35 | 1.6% | 0.125 | 0.4% |
membrane | 33.5% | 1 | 58.9% | 9.68E-05 | 42.8% |
plasma membrane | 14.5% | 1 | 40.5% | 1.81E-09 | 19.9% |
extracellular region | 5.6% | 1 | 22.7% | 2.27E-04 | 11.8% |
integral to plasma membrane | 4.5% | 1 | 22.2% | 1.04E-09 | 7.0% |
vesicle | 4.1% | 0.023 | 14.1% | 7.09E-10 | 2.8% |
vacoule | 1.5% | 0.475 | 10.3% | 6.25E-10 | 1.4% |
lysosome | 1.2% | 0.705 | 9.2% | 2.12E-09 | 1.2% |
pigment granule | 2.3% | 1.65E-09 | 8.6% | 1.27E-13 | 0.5% |
melanosome | 2.3% | 1.65E-09 | 8.6% | 1.27E-13 | 0.5% |
Fractions and the corresponding p-values for some of the most significantly enriched terms are marked in bold. The p-values have been corrected for multiple testing by the Benjamini & Hochberg correction method.