Table 2. Phenolic substrates of MelC2 and MelD2 and effect on toxicity.

	MelC2	MelD2
Compound	Substrate	Increased toxicity	Substrate	Decreased toxicity
Catechol	+ 1, 2, 4	+	+	+
Phenol	+ 2, 4	+	+	+
4-Methylcatechol	+ 2, 3	+	+	+
Gallic acid	+	+	+	+
Caffeic acid	+ 1	+	−	−
o-aminophenol	+ 4	+	−	−
Ferulic acid	N.D.	+	N.D.	±
3,4-Dihydroxybenzoic acid	+ 1	+	N.D.	−
Salicylic acid	N.D.	+	N.D.	−

All enzyme activities were determined in this study except for those marked ‘N. D.’ (not determined) and the MelC2 activity on 3,4-dihydroxybenzoic acid, which was based on the reference. References: 1. [34]; 2. [35]; 3. [36]; 4. [37]. ‘±’, slight effect.