Table 3.
Congenital malformations and neuroblastoma
| Controls n = 1681 | Neuroblastoma |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| All neuroblastoma | MYCN non-amplified | MYCN amplified | ||||||||
| n = 191 | OR1 | 95% CI2 | n = 144 | OR | 95% CI | n = 35 | OR | 95% CI | ||
| Any malformations | ||||||||||
| No | 1624 | 179 | 1.0 | reference | 136 | 1.0 | reference | 32 | 1.0 | reference |
| Yes | 57 | 12 | 2.2 | (1.1–4.5) | 8 | 2.0 | (0.9–4.7) | 3 | 3.3 | (0.9–12) |
| 1 | 51 | 10 | 2.1 | (1.0–4.6) | 7 | 2.0 | (0.8–4.9) | 2 | 2.7 | (0.6–12) |
| 2/over | 6 | 2 | 3.1 | (0.6–17) | 1 | 2.3 | (0.3–20) | 1 | 6.4 | (0.7–62) |
| ptrend = 0.03 | ptrend = 0.12 | ptrend = 0.04 | ||||||||
| Minor malformations | 19 | 2 | 1.7 | (0.4–7.7) | 2 | 2.4 | (0.5–11) | 0 | - | - |
| Major malformations | 38 | 10 | 2.4 | (1.1–5.4) | 6 | 1.9 | (0.7–5.2) | 3 | 4.4 | (1.2–16) |
| Malformation location | ||||||||||
| Heart | 5 | 0 | 0 | - | 0 | - | - | 0 | - | - |
| Digestive system | 2 | 1 | 4.6 | (0.3–69) | 1 | 6.8 | (0.5–102) | 0 | - | - |
| Urinary system | 10 | 4 | 4.4 | (1.1–17) | 3 | 4.4 | (1.0–20) | 1 | 6.4 | (0.6–64) |
| Genital organs | 6 | 1 | 1.7 | (0.2–15) | 0 | - | - | 1 | 5.4 | (0.5–54) |
| Skeleton | 22 | 5 | 3.3 | (1.1–9.6) | 3 | 3.0 | (0.8–11) | 1 | 3.6 | (0.4–31) |
| Minor | 8 | 2 | 5.1 | (0.9–29) | 2 | 7.7 | (1.3–44) | 0 | - | - |
| Major | 14 | 3 | 2.6 | (0.7–10) | 1 | 1.3 | (0.2–11) | 1 | 6.1 | (0.6–58) |
| Others | 2 | 14 | 0.7 | (0.1–5.7) | 1 | <0.001 | (<0.001–>999) | 1 | 5.2 | (0.5–51) |
1
Odds ratios adjusted for age and gender;
2
95% CI: 95% Confidence Interval