Table 4.

Maternal reproductive history and neuroblastoma

	Controls n = 1681	Neuroblastoma
		All neuroblastoma			MYCN non-amplified			MYCN amplified
		n = 191	OR1	95% CI2	n = 144	OR	95% CI	n = 35	OR	95% CI
Any fetal losses
No	1031	129	1.0	reference	101	1.0	reference	20	1.0	reference
Yes	650	62	0.9	(0.6–1.2)	43	0.8	(0.5–1.2)	15	1.3	(0.6–2.6)
1	403	44	1.0	(0.7–1.5)	30	0.9	(0.5–1.4)	10	1.4	(0.6–3.1)
2+	247	18	0.7	(0.4–1.1)	13	0.6	(0.3–1.2)	5	1.1	(0.4–3.2)
Spontaneous abortions
No	1239	160	1.0	reference	124	1.0	reference	26	1.0	reference
Yes	442	31	0.6	(0.4–0.9)	20	0.5	(0.3–0.8)	9	1.0	(0.5–2.2)
1	303	24	0.7	(0.4–1.1)	16	0.6	(0.3–1.1)	6	1.0	(0.4–2.6)
2+	138	7	0.4	(0.2–0.9)	4	0.3	(0.1–0.8)	3	1.0	(0.3–3.4)
Abortions
No	1429	158	1.0	reference	119	1.0	reference	29	1.0	reference
Yes	252	33	1.4	(0.9–2.2)	25	1.4	(0.9–2.4)	6	1.3	(0.5–3.3)
1	209	27	1.3	(0.8–2.2)	19	1.3	(0.7–2.2)	6	1.6	(0.6–3.9)
2+	43	6	1.7	(0.7–4.5)	6	2.4	(0.9–6.4)	0	-	-
Termination of pregnancy
No	1594	185	1.0	reference	140	1.0	reference	33	1.0	reference
Yes	87	6	0.7	(0.3–1.7)	4	0.6	(0.2–1.9)	2	1.3	(0.3–5.6)
For malformations	14	2	1.1	(0.2–5.6)	1	0.8	(0.1–6.4)	1	3.3	(0.4–30)
Other	73	4	0.6	(0.2–1.7)	3	0.6	(0.2–2.1)	1	0.8	(0.1–6.0)
Use of fertility treatments (index child)
No	1599	182	1.0	reference	139	1.0	reference	32	1.0	reference
Yes	82	9	0.9	(0.4–2.0)	5	0.7	(0.3–1.8)	3	1.6	(0.5–5.6)
Stimulation only	41	5	1.0	(0.4–2.9)	3	0.8	(0.2–2.8)	2	2.6	(0.6–12)
In vitro fertilization	22	3	1.3	(0.4–4.6)	1	0.6	(0.1–4.4)	1	1.8	(0.2–15)
Artificial insemination	22	2	0.8	(0.2–3.9)	1	0.5	(0.1–4.2)	0	-	-

¹Odds ratios adjusted for age and gender;

²95% CI: 95% Confidence Interval