Table 1.
Input parameter values for NORM and PH simulations
| Parameter | Unit | Value |
|---|---|---|
| Hemodynamics at rest | ||
| Mean systemic arterial blood pressure | kPa | 12.2 |
| Mean systemic blood flow | mL s−1 | 85 |
| Cardiac cycle time | s | 0.850 |
| Mean pulmonary arteriovenous pressure drop | kPa | 1.5 (NORM) |
| Interventions with exercise | ||
| Mean systemic blood flow | mL s−1 | 255 |
| Cardiac cycle time | s | 0.425 |
| Set point values for adaptation | ||
| Mean flow velocity in large blood vessels (rest) | m s−1 | 0.17 |
| Maximum vascular wall stress (exercise) | kPa | 500 |
| Maximum sarcomere length (exercise) | μm | 2.2 |
| Minimum sarcomere length (exercise) | μm | 1.75 |
| Maximum passive myofiber stress (exercise) | kPa | 10 (LW), 8 (SW), 20 (RW) |
| Interventions with PH simulations | ||
| Mean pulmonary arteriovenous pressure drop | kPa | 3.0 (PHAc1 and PHCh1), 4.5 (PHAc2 and PHCh2), 6.0 (PHAc3 and PHCh3) |
| Parameter values for model initialization | ||
| Wall volume (Vw) | mL | 75 (LW), 40 (SW), 30 (RW) |
| Reference midwall surface area (Am,ref) | cm2 | 80 (LW), 45 (SW), 100 (RW) |
| Reference sarcomere length (Ls,ref) | μm | 2.0 (LW, SW, and RW) |
| Septal midwall volume (Vm,SW) | mL | 42 |
| Radius of midwall junction circle (ym) | cm | 3.3 |
LW, left ventricular free wall; NORM, normal simulation; PHAc, acute pulmonary hypertension simulation; PHCh, chronic pulmonary hypertension simulation; RW, right ventricular free wall; SW, septal wall