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. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: Cancer Res. 2009 Jul 7;69(14):5918–5926. doi: 10.1158/0008-5472.CAN-08-4623

Figure 5.

Figure 5

Activation of the PI3K/Akt pathway in Tgfbr1 cKO mice. A, Immunostaining revealed a significantly increased number of positive cells of p-Akt, p-mTOR in the SCCs that developed in Tgfbr1 cKO mice. The dotted lines delineate the adjacent epithelial compartment. Bar, 50 μm. B, A significantly increased level of unphosphorylated PTEN, an active form of the protein, was detected in all SCCs that developed in the DMBA-treated Tgfbr1 cKO mice. However, comparable elevated levels of the phosphorylated form of Akt (p-Akt) were also observed in SCCs by Western blot analysis.