Table 1.
Adjusted ORs and 95%CIs for colon cancer by genotype and race
| African Americans | Whites | |||||
|---|---|---|---|---|---|---|
| Cases/Controls | OR* | 95% CI | Cases/Controls | OR* | 95%CI | |
| SHMT 1420 | ||||||
| CC | 106/153 | 1.0 | Ref | 151/257 | 1.0 | Ref |
| CT | 105/130 | 1.2 | 0.9, 1.8 | 128/205 | 1.0 | 0.8, 1.4 |
| TT | 28/39 | 1.1 | 0.6, 1.8 | 28/71 | 0.6 | 0.4, 1.0 |
| CT, TT | 133/169 | 1.2 | 0.8, 1.7 | 156/276 | 0.9 | 0.7, 1.3 |
| MTRR 66 | ||||||
| GG | 24/26 | 1.0 | Ref | 99/168 | 1.0 | Ref |
| AG | 99/127 | 1.0 | 0.5, 1.8 | 155/256 | 1.0 | 0.8, 1.4 |
| AA | 116/169 | 0.9 | 0.5, 1.6 | 53/109 | 0.8 | 0.5, 1.2 |
| AG, AA | 215/296 | 0.9 | 0.5, 1.7 | 208/365 | 1.0 | 0.7, 1.3 |
| MTR 2756 | ||||||
| AA | 129/182 | 1.0 | Ref | 205/347 | 1.0 | Ref |
| AG | 94/125 | 1.1 | 0.8, 1.5 | 91/171 | 0.9 | 0.7, 1.3 |
| GG | 16/15 | 1.4 | 0.6, 2.9 | 11/15 | 1.2 | 0.6, 2.8 |
| AG, GG | 110/140 | 1.1 | 0.8, 1.6 | 102/186 | 0.9 | 0.7, 1.3 |
| # Variant Alleles§ | ||||||
| 0 or 1 | 19/34 | 1.0 | Ref | 36/57 | 1.0 | Ref |
| 2 or 3 | 124/167 | 1.6 | 0.9, 3.0 | 172/255 | 1.1 | 0.7, 1.7 |
| 4 or 5 | 87/108 | 1.7 | 0.9, 3.3 | 84/195 | 0.7 | 0.4, 1.1 |
| 6 or more | 9/13 | 1.5 | 0.5, 4.4 | 15/26 | 0.9 | 0.4, 1.9 |
*
Adjusted for offset terms, age, and gender
§
Includes SNPs listed in table and MTHFR C677T and A1298C; variant allele defined as follows: MTHFR 677:T; MTHFR 1298:C; SHMT 1420:T; MTRR 66:A; and MTR 2756:G.