Table 2.
Joint effects of individual and combined SNPs and folate intake on colon cancer risk by race
| African Americans | Whites | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases/ Controls |
OR* | 95%CI | Cases/ Controls |
OR* | 95%CI | Cases/ Controls |
OR* | 95%CI | Cases/ Controls |
OR* | 95%CI | |
| Low folate <400ug | High folate >=400ug | Low folate <400ug | High folate >=400ug | |||||||||
| SHMT 1420 | ||||||||||||
| CC | 72/93 | 1.0 | Ref | 31/54 | 0.7 | 0.4, 1.2 | 94/121 | 1.0 | Ref | 53/129 | 0.5 | 0.3, 0.8 |
| CT | 67/85 | 1.0 | 0.7, 1.7 | 34/42 | 1.0 | 0.6, 1.8 | 68/97 | 0.9 | 0.6, 1.3 | 57/100 | 0.7 | 0.5, 1.1 |
| TT | 19/27 | 0.9 | 0.4, 1.7 | 8/12 | 0.9 | 0.3, 2.3 | 13/32 | 0.5 | 0.3, 1.1 | 15/37 | 0.5 | 0.2, 0.9 |
| CT, TT | 86/112 | 1.0 | 0.7, 1.5 | 42/54 | 1.0 | 0.6, 1.7 | 81/129 | 0.8 | 0.5, 1.2 | 72/137 | 0.7 | 0.4, 1.0 |
| ICR= 0.34 (95% CI −0.29, 0.96), p = 0.29 | ICR= 0.33 (95% CI −0.05, 0.71), p= 0.09 | |||||||||||
| LRT p= 0.29 | LRT p= 0.13 | |||||||||||
| MTRR 66 | ||||||||||||
| GG | 16/19 | 1.0 | Ref | 7/7 | 1.0 | 0.3, 3.8 | 63/74 | 1.0 | Ref | 34/91 | 0.4 | 0.2, 0.7 |
| AG | 67/78 | 1.2 | 0.5, 2.5 | 27/44 | 0.8 | 0.3, 1.8 | 82/126 | 0.8 | 0.5, 1.2 | 69/121 | 0.7 | 0.4, 1.0 |
| AA | 75/108 | 1.0 | 0.4, 2.0 | 39/57 | 0.9 | 0.4, 2.1 | 30/50 | 0.7 | 0.4, 1.2 | 22/54 | 0.5 | 0.3, 0.9 |
| AG, AA | 142/186 | 1.0 | 0.5, 2.2 | 66/101 | 0.9 | 0.4, 1.8 | 112/176 | 0.7 | 0.4, 1.1 | 91/175 | 0.6 | 0.4, 0.9 |
| ICR= −0.24 (95% CI −1.71, 1.23), p= 0.75 | ICR= 0.44 (95% CI 0.09, 0.78), p= 0.01 | |||||||||||
| LRT p= 0.71 | LRT p= 0.04 | |||||||||||
| MTR 2756 | ||||||||||||
| AA | 87/114 | 1.0 | Ref | 36/62 | 0.7 | 0.4, 1.2 | 121/164 | 1.0 | Ref | 82/168 | 0.6 | 0.5, 0.9 |
| AG | 64/81 | 1.0 | 0.7, 1.6 | 28/41 | 0.9 | 0.5, 1.6 | 48/80 | 0.8 | 0.5, 1.3 | 39/89 | 0.6 | 0.4, 0.9 |
| GG | 7/10 | 0.8 | 0.3, 2.3 | 9/5 | 2.0 | 0.6, 6.4 | 6/6 | 1.3 | 0.4, 4.3 | 4/9 | 0.6 | 0.2, 2.1 |
| AG, GG | 71/91 | 1.0 | 0.7, 1.5 | 37/46 | 0.7 | 0.6, 1.7 | 54/86 | 0.9 | 0.6, 1.3 | 43/98 | 0.6 | 0.4, 0.9 |
| ICR= 0.29 (95% CI −0.36, 0.95), p= 0.38 | ICR= 0.07 (95% CI −0.39, 0.53), p= 0.77 | |||||||||||
| LRT p= 0.36 | LRT p= 0.89 | |||||||||||
| # Variant Alleles§ | ||||||||||||
| 0 or 1 | 15/18 | 1.0 | Ref | 4/15 | 0.2 | 0.1, 0.8 | 26/24 | 1.0 | Ref | 9/31 | 0.2 | 0.1, 0.6 |
| 2 or 3 | 81/107 | 1.0 | 0.4, 2.1 | 36/55 | 0.8 | 0.4, 1.9 | 99/114 | 0.8 | 0.4, 1.4 | 69/134 | 0.5 | 0.2, 0.8 |
| 4 or 5 | 58/70 | 1.1 | 0.5, 2.3 | 28/36 | 1.0 | 0.4, 2.3 | 43/98 | 0.4 | 0.2, 0.8 | 39/89 | 0.4 | 0.2, 0.8 |
| 6 or more | 4/10 | 0.5 | 0.1, 2.0 | 5/2 | 3.4£ | 0.6, 20.3 | 7/14 | 0.5 | 0.2, 1.3 | 8/12 | 0.5 | 0.2, 1.6 |
| LRT p= 0.05 | LRT p= 0.04 | |||||||||||
*
Adjusted for offset terms, age, and gender
§
Includes SNPs listed in table and MTHFR C677T and A1298C; variant allele defined as follows: MTHFR 677:T; MTHFR 1298:C; SHMT 1420:T; MTRR 66:A; and MTR 2756:G.
£
This OR is based on extremely small numbers and thus, is an unstable estimate.