Table 3.
Joint effects of individual and combined SNPs and alcohol intake on colon cancer risk by race
| African Americans | Whites | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases/ Controls |
OR* | 95%CI | Cases/ Controls |
OR* | 95%CI | Cases/ Controls |
OR* | 95%CI | Cases/ Controls |
OR* | 95%CI | |
| Drinker | Non-Drinker | Drinker | Non-Drinker | |||||||||
| SHMT 1420 | ||||||||||||
| CC | 22/18 | 1.0 | Ref | 81/129 | 0.5 | 0.3, 1.1 | 52/102 | 1.0 | Ref | 95/148 | 1.3 | 0.9, 2.0 |
| CT | 23/30 | 0.6 | 0.3, 1.5 | 78/98 | 0.7 | 0.4, 1.5 | 57/79 | 1.4 | 0.9, 2.3 | 68/118 | 1.2 | 0.7, 1.9 |
| TT | 4/12 | 0.3 | 0.1, 1.0 | 23/27 | 0.8 | 0.3, 1.8 | 10/27 | 0.7 | 0.3, 1.6 | 18/42 | 0.8 | 0.4, 1.6 |
| CT, TT | 27/42 | 0.5 | 0.2, 1.2 | 101/125 | 0.7 | 0.4, 1.5 | 67/106 | 1.2 | 0.8, 2.0 | 86/160 | 1.1 | 0.7, 1.7 |
| ICR= 0.66 (95% CI 0.24, 1.08), p= 0.002 | ICR= −0.50 (95% CI −1.28, 0.28), p= 0.21 | |||||||||||
| LRT p= 0.04 | LRT p= 0.15 | |||||||||||
| MTRR 66 | ||||||||||||
| GG | 4/3 | 1.0 | Ref | 19/23 | 0.7 | 0.1, 3.7 | 37/65 | 1.0 | Ref | 60/100 | 1.1 | 0.7, 1.9 |
| AG | 30/32 | 0.9 | 0.2, 4.3 | 64/91 | 1.7 | 0.1, 3.3 | 64/96 | 1.2 | 0.7, 2.0 | 87/151 | 1.1 | 0.7, 1.8 |
| AA | 15/25 | 0.6 | 0.1, 3.0 | 99/140 | 1.7 | 0.1, 3.4 | 18/47 | 0.7 | 0.3, 1.4 | 34/57 | 1.1 | 0.6, 2.0 |
| AG, AA | 45/57 | 0.7 | 0.2, 3.6 | 163/231 | 0.7 | 0.2, 3.3 | 82/143 | 1.0 | 0.6, 1.7 | 121/208 | 1.1 | 0.7, 1.7 |
| ICR= 0.26 (95% CI −0.99, 1.51), p= 0.68 | ICR= −0.06 (95% CI −0.74, 0.61), p= 0.86 | |||||||||||
| LRT p= 0.73 | LRT p= 0.85 | |||||||||||
| MTR 2756 | ||||||||||||
| AA | 32/40 | 1.0 | Ref | 91/136 | 0.9 | 0.5, 1.7 | 79/137 | 1.0 | Ref | 124/195 | 1.1 | 0.8, 1.6 |
| AG | 16/18 | 1.3 | 0.5, 2.9 | 76/105 | 1.0 | 0.6, 1.8 | 37/66 | 1.0 | 0.6, 1.6 | 50/103 | 0.9 | 0.6, 1.4 |
| GG | 1/2 | 0.6 | 0.1, 7.0 | 15/13 | 1.4 | 0.6, 3.5 | 3/5 | 1.1 | 0.2, 4.7 | 7/10 | 1.3 | 0.5, 3.6 |
| AG, GG | 17/20 | 1.2 | 0.5, 2.7 | 91/118 | 1.1 | 0.6, 1.8 | 40/71 | 1.0 | 0.6, 1.6 | 57/113 | 0.9 | 0.6, 1.4 |
| ICR= −0.08 (95% CI −1.09, 0.94), p= 0.88 | ICR= −0.19 (95% CI −0.83, 0.46), p= 0.57 | |||||||||||
| LRT p= 0.90 | LRT p= 0.57 | |||||||||||
| # Variant Alleles§ | ||||||||||||
| 0 or 1 | 4/5 | 1.0 | Ref | 15/28 | 0.7 | 0.1, 3.0 | 8/16 | 1.0 | Ref | 27/39 | 1.4 | 0.5, 3.7 |
| 2 or 3 | 32/30 | 1.5 | 0.4, 6.3 | 85/132 | 1.0 | 0.3, 4.1 | 68/113 | 1.2 | 0.5, 2.9 | 100/135 | 1.5 | 0.6, 3.7 |
| 4 or 5 | 10/22 | 0.7 | 0.1, 3.2 | 76/85 | 1.3 | 0.3, 5.3 | 39/66 | 1.2 | 0.5, 3.0 | 43/121 | 0.7 | 0.3, 1.8 |
| 6 or more | 3/3 | 1.4 | 0.2,11.8 | 6/9 | 1.1 | 0.2, 6.0 | 4/13 | 0.6 | 0.3, 2.3 | 11/13 | 1.7 | 0.5, 5.4 |
| LRT p= 0.23 | LRT p= 0.06 | |||||||||||
*
Adjusted for offset terms, age, and gender
§
Includes SNPs listed in table and MTHFR C677T and A1298C; variant allele defined as follows: MTHFR 677:T; MTHFR 1298:C; SHMT 1420:T; MTRR 66:A; and MTR 2756:G.