Table 3.
Perinatal outcomes associated with first subsequent offspring among male survivors versus a comparison group.1
| Cohort, N (%) |
Relative Risk (95% CI)2 | ||
|---|---|---|---|
| Outcome | Cancer survivors (n=470) | Comparison group (n=4150) | |
| Maternal conditions | |||
| Any history of C-section | 84 (18.5) | 721 (18.0) | 0.91 (0.73−1.14) |
| Primary C-section3 | 65 (19.2) | 374 (19.4) | 0.91 (0.71−1.17) |
| Diabetes4 | 9 (2.2) | 71 (2.0) | 1.17 (0.55−2.51) |
| Preeclampsia/eclampsia4 | 27 (6.5) | 160 (4.4) | 1.19 (0.76−1.88) |
| Anemia4 | 3 (0.8) | 79 (2.3) | 0.46 (0.13−1.55) |
| Infant outcomes | |||
| Female gender | 225 (47.9) | 2033 (49.0) | referent |
| Male gender | 245 (52.1) | 2117 (51.0) | 1.03 (0.93−1.14) |
| Birth weight, grams | |||
| <2500 | 41 (8.7) | 282 (6.8) | 1.43 (0.99−2.05) |
| 2500−3999 | 380 (80.9) | 3465 (83.6) | referent |
| ≥4000 | 49 (10.4) | 397 (9.6) | 1.08 (0.79−1.49) |
| Gestational age, weeks | |||
| <37 | 42 (9.1) | 366 (9.0) | 0.99 (0.70−1.41) |
| 37−41 | 381 (82.5) | 3383 (83.5) | referent |
| ≥42 | 39 (8.4) | 305 (7.5) | 1.18 (0.85−1.64) |
| Small for gestational age | 43 (9.4) | 414 (10.3) | 0.91 (0.64−1.29) |
| Malformation4 | 9 (2.0) | 86 (2.1) | 0.83 (0.41−1.69) |
| 5-minute Apgar <75 | 4 (1.1) | 57 (1.6) | 0.81 (0.29−2.29) |
| Infant death6 | 0 | 20 (0.6) | - |
1
Numbers may not add up to totals because of missing data.
2
Adjusted for state, infant birth year, paternal and maternal age, paternal race/ethnicity, and maternal parity.
3
Among 345 male cancer survivors and 1979 comparison men whose partners did not have prior deliveries.
4
Not available for all years.
5
Not available for all years and unavailable in Michigan.
6
Not available for all years and unavailable in Georgia.