Table 4.
Pregnancy outcomes associated with first subsequent birth among childhood cancer and adolescent cervical/genital cancer cases versus a comparison group.1
| Cohort, N (%) | Relative Risk (95% CI)2 | |||||
|---|---|---|---|---|---|---|
| Outcome | Childhood cancer (n=892) |
Cervical/ genital cancer (n=1006) |
Comparison (n=14278) |
Childhood cancer |
Cervical/ genital cancer |
|
| Maternal conditions | ||||||
| Any C-section3 | 163 (21.5) | 154 (17.2) | 2212 (17.1) | 1.15 (0.99-1.33) | 0.97 (0.83-1.13) | |
| Primary C-section4 | 145 (21.8) | 110 (20.8) | 1216 (18.5) | 1.14 (0.97-1.33) | 1.11 (0.92-1.32) | |
| Diabetes3 | 11 (1.6) | 13 (1.5) | 174 (1.4) | 1.02 (0.53-1.95) | 0.86 (0.49-1.53) | |
| Preeclampsia3 | 37 (5.4) | 34 (3.9) | 452 (3.7) | 1.01 (0.73-1.42) | 0.99 (0.70-1.41) | |
| Anemia3 | 18 (2.7) | 12 (1.4) | 269 (2.3) | 1.30 (0.81-2.08) | 0.65 (0.36-1.17) | |
| Infant outcomes | ||||||
| Female gender | 444 (49.8) | 507 (50.4) | 7058 (49.4) | referent | referent | |
| Male gender | 448 (50.2) | 499 (49.6) | 7220 (50.6) | 1.00 (0.93-1.07) | 0.97 (0.90-1.03) | |
| Gestational age (weeks) | ||||||
| <37 | 130 (14.9) | 145 (14.8) | 1423 (10.3) | 1.54 (1.30-1.83) | 1.33 (1.13-1.56) | |
| 37-41 | 677 (77.4) | 747 (76.2) | 11088 (79.9 | referent | referent | |
| ≥42 | 68 (7.8) | 89 (9.1) | 1371 (9.9) | 0.86 (0.68-1.08) | 0.91 (0.74-1.11) | |
| Birth weight (grams)5 | ||||||
| <2500 | 103 (11.6) | 122 (12.2) | 1081 (7.6) | 1.31 (1.10-1.57) | 1.29 (1.10-1.53) | |
| 2500-3999 | 708 (79.5) | 813 (81.1) | 11917 (83.6) | referent | referent | |
| ≥4000 | 80 (9.0) | 68 (6.8) | 1256 (8.8) | 1.18 (0.94-1.48) | 0.89 (0.70-1.14) | |
| Small for gestational age6 | 96 (11.1) | 149 (15.3) | 1549 (11.3) | 0.87 (0.67-1.12) | 1.09 (0.90-1.33) | |
| Malformation3 | 10 (1.3) | 14 (1.6) | 220 (1.7) | 0.92 (0.48-1.75) | 1.16 (0.66-2.04) | |
| 5-min Apgar <77 | 13 (2.4) | 15 (3.3) | 172 (1.7) | 1.30 (0.72-2.35) | 2.01 (1.15-3.50) | |
| Infant death8 | 7 (1.0) | 6 (0.7) | 93 (0.9) | 1.08 (0.47-2.48) | 0.83 (0.36-1.89) | |
1
Numbers may not add up to totals because of missing data.
2
Adjusted for state, maternal age, year of delivery, race/ethnicity, and parity.
3
Not available all years.
4
Among 679 childhood cancer cohort members, 539 genital tract cases, and 6804 comparison women without prior deliveries.
5
Also adjusted by gestational length (<32, 32-36, 37-41, ≥42 weeks).
6
Also adjusted for maternal prenatal smoking.
7
Not available all years, unavailable in Michigan.
8
Not available all years, unavailable in Georgia.